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The sequence of Xp54 is hy conserved in a wide spectrum of organisms.

Xp54 and related DDX6-like RNA helicases roles in messenger.

The versatility of Xp54 and related helicases in modulating the metabolism of m RNAs at all stages of their lifetimes marks them out as key regulators of post-transcriptional gene expression.

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In oocytes, several abundant proteins bind pre-m RNA transcripts to modulate nuclear export, RNA stability and translational fate.

M12M Replacement Receiver User Manual - Jackson Labs.

Like Xp54, CGH-1 are required for proper meiotic development, apparently by regulating the translational activation of stored m RNPs and also for sorting certain m RNPs into germplasm-containing structures.


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